A patient on antihypertensive medication for four years reports blurred vision. Which other manifestations could indicate target organ disease?

The identification of aneurysm as a manifestation that could indicate target organ disease in a patient with a history of hypertension is significant. Hypertension can lead to structural changes in blood vessels and damage to target organs such as the brain, kidneys, eyes, and heart. An aneurysm, which is an abnormal bulging of a blood vessel wall, can occur as a result of the high pressure exerted on the vessel walls over time, leading to a weakening of those walls.

In the context of hypertension, the presence of an aneurysm is particularly concerning as it suggests potential significant vascular damage and the risk of complications, including rupture and hemorrhage. This aligns with the concept of target organ damage, wherein chronic hypertension adversely affects vital organs and can lead to life-threatening situations.

Other options, such as fever and chills, do not relate directly to the consequences of high blood pressure on the vasculature or target organs. Headache can occur due to various reasons, including hypertension, but it is less specific as an indicator of target organ damage compared to an aneurysm. Increased appetite is generally not associated with complications of hypertension or its effects on target organ health.